|
KMID : 0603520000050040186
|
|
Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 4 p.186 ~ p.192
|
|
|
Anticarcinogenicity of Various Ginseng Fractions and Components in Red Ginseng Using Yun’s Anticarcinogenicity Test Model
|
|
Yun Taik-Koo
Lee Yun-Sil
Choi Kwang-Joo
Lee You-Hui
Yun Hyo-Yung
|
|
|
Abstract
|
|
|
|
Cancer could be conquered by early diagnosis and primary prevention through many non-toxic cancer preventives ’neutraceutical’ have been discovered Our study has been focused on the anticarcinogenicity of Panax ginseng C. A. Meyer, also known as mystic tonic, against various chemical carcinogens. Experimental and epidemiological findings showed that red ginseng and heated fresh ginseng extract had anticarcinogenic and cancer preventive effects. To identify its active components, several extracts and components of red ginseng and fresh ginseng were tested for anticarcinogenicity using Yun’s 9 week medium term assay. Ethanol extract, water extract and total saponin fraction isolated from 6 year-old fresh ginseng significantly inhibited mouse lung adenoma incidence, suggesting that saponin might be the active components. Furthermore, since red ginseng among the ginseng types, showed the most effective anticarcinogenicity, semi-synthesized ginsenoside Rg3 and Rg5 mixture, major saponi n components in red ginseng, were selected for further study. The results showed significant inhibition of lung adenoma in Yun’s anticarcinogenicity test system, indicating that ginsenoside Rg3 or Rg5 alone or together would be active anticarcinogenic compounds.
|
|
|
KEYWORD
|
|
|
Anticarcinogenicity, Ginseng, Red ginseng, Ginseng fractions, Minor ginsenosides
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
|
|
|